三七皂甙 R1
三七皂甙 R1(netoginsenoside R1)
CAS: 80418-24-2
化学式: C47H80O18
| 中文名 | 三七皂甙 R1 |
| 英文名 | netoginsenoside R1 |
| 别名 | 三七皂苷 三七皂苷R1 三七皂甙R1 三七皂苷 R1 三七皂甙 R1 三七皂苷R1标准品 三七皂甙R1(标准品) 三七皂苷R1(分析标准品) 三七皂苷 R1, 来源于三七 NOTOGINSENOSIDE R1 三七皂苷R1 标准品 |
| 英文别名 | Netoginsenoside Sanchinoside R1 NOTOGINSENOSIDE netoginsenoside R1 Notoginsenoside R1 Notoginsenoside Fb NOTOGINSENOSIDE R1 Notoginsenoside R 1 NOTOGINSENOSIDE R1(SH) glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl2-O-β-D-xylopyranosyl- (3β,6α,12β)-20-(β-D-Glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-β-D-xylopyranosyl-β-D-glucopyranoside (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside beta-D-Glucopyranoside, (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl- (6beta,8xi,9xi,12alpha,13xi,14beta)-17-[(1S)-1-(beta-D-glucopyranosyloxy)-1,5-dimethylhex-4-en-1-yl]-3,12-dihydroxy-4,4,10,14-tetramethylgonan-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside |
| CAS | 80418-24-2 |
| 化学式 | C47H80O18 |
| 分子量 | 933.14 |
| InChI | InChI=1/C47H80O18/c1-21(2)10-9-13-47(8,65-41-37(59)34(56)32(54)26(18-48)62-41)22-11-15-45(6)30(22)23(50)16-28-44(5)14-12-29(52)43(3,4)39(44)25(17-46(28,45)7)61-42-38(35(57)33(55)27(19-49)63-42)64-40-36(58)31(53)24(51)20-60-40/h10,22-42,48-59H,9,11-20H2,1-8H3/t22-,23+,24+,25-,26+,27+,28+,29-,30-,31-,32+,33+,34-,35-,36+,37+,38+,39-,40-,41-,42+,44+,45+,46+,47-/m0/s1 |
| InChIKey | LLPWNQMSUYAGQI-OOSPGMBYSA-N |
| 密度 | 1.39±0.1 g/cm3(Predicted) |
| 熔点 | 215～217℃ |
| 沸点 | 1010.5±65.0 °C(Predicted) |
| 比旋光度 | (c, 1.0 in MeOH)+15 |
| 闪点 | 564.9°C |
| 蒸汽压 | 0mmHg at 25°C |
| 溶解度 | H2O: 可溶物1mg/mL，澄清，无色 |
| 折射率 | 1.614 |
| 酸度系数 | 12.85±0.70(Predicted) |
| 存储条件 | Sealed in dry,Room Temperature |
| 敏感性 | Easily absorbing moisture |
| 外观 | 粉末 |
| 颜色 | white to off-white |
| 物化性质 | 来源于五加科(araliaceae)人参属植物的干燥根 |
| MDL号 | MFCD00210535 |
| 危险品标志 | Xn - 有害物品 |
| 风险术语 | 22 - 吞食有害。 |
| 安全术语 | 24/25 - 避免与皮肤和眼睛接触。 |
| WGK Germany | 3 |
| 海关编号 | 29389090 |
| 参考资料 展开查看 | 1. 杨丹 姜岚 朱梅 等. PLGA携三七皂苷Rb1微球的制备及实验条件优化研究[J]. 中国医学创新 2020 017(003):151-154. 2. 杨丹 姜岚 黄娟 等. 三七皂苷R1-PLGA纳米微球的制备及优化研究[J]. 化学与粘合 2020 v.42;No.190(02):16-19+23. 3. 任民 徐革 彭伟 何吉洪 陈和平.三七皂苷R1对缺氧诱导PC12细胞损伤的保护作用[J].中国临床药理学杂志 2020 36(12):1657-1660. 4. 普显宏 何媛 黄微 茹金 杨金伟.三七皂苷R1对肝纤维化大鼠TGF-β1/Smad3信号的影响[J].现代生物医学进展 2015 15(04):622-626. 5. 熊敏琪 陈瑜 张腾. 三七皂苷R1抑制ApoE基因敲除小鼠肝脏脂质沉积的作用及其机制研究[J]. 上海中医药杂志 2018 v.52；No.580(05):71-76. 6. 赵志新 胡小铭 汪杰 柴海飞.三七皂苷R_1对大鼠脑缺血-再灌注损伤后TNF-α mRNA的影响[J].浙江创伤外科 2017 22(01):13-16. 7. 刘梦楠 王敏 白玉莹 等. 包装对三七粉和熟三七粉稳定性的影响研究[J]. 世界中医药 2020年15卷13期 1891-1896页 ISTIC 2020. 8. 韩柱, 崔波, 陆菁,等. 清肠栓质量标准研究[J]. 中成药, 2016, 38(008):1749-1753. 9. 刘梦楠 薛雪 熊慧 等. 不同净制工艺对三七质量的影响[J]. 世界中医药 2019 v.14(02):56-59+64. 10. 吴朕 茹金 樊楚明 等. 三七皂苷R1保护四氯化碳诱导肝纤维化模型大鼠的作用[J]. 中国组织工程研究 2020 024(026):4213-4217. 11. 袁明洋 金司仪 黄壮 等. 不同粒度对三七粉主要有效成分体外溶出度的影响[J]. 食品安全质量检测学报 2020 v.11(06):234-238. 12. 孙孔春 吴乐艳 侯雯清 等. 云南省不同产地三七的成分分析[J]. 昆明医科大学学报 2020 041(001):P.1-10. 13. 于颖超, 倪健, 陈功森,等. 芪箭颗粒中皂苷类成分与莫诺苷的指纹图谱研究[J]. 中南药学, 2019(12). 14. 刘芳, 赵瀚森, 孙公伟,等. 基质辅助激光解析质谱成像可视化分析三七皂苷空间分布. 15. 张永 陈旭 丁越 等. HPLC法结合统计学方法研究复方丹参片中皂苷类成分[J]. 辽宁中医杂志 2019 46(01):126-129. 16. 吴雨佳, 王令充, 张雯,等. 生物黏附性三七总皂苷-白及多糖-海藻酸钠复合微球的制备及表征[J]. 中草药, 2019, v.50;No.655(20):49-56. 17. 杜静. 冠突散囊菌对中药材三七成分的转化及机理研究[D].贵州师范大学,2020. 18. 乐世俊,王文晓,高欢,任继国,付瑞嘉,李佳佳,陈艳琰,唐于平.HPLC同时测定不同厂家丹七片中多个有效成分的含量[J].药物分析杂志,2020,40(12):2236-2243. 19. Ting Wang, Daqian Wan, Lei Shao, Jiezhi Dai, Chaoyin Jiang, Notoginsenoside R1 stimulates osteogenic function in primary osteoblasts via estrogen receptor signaling, Biochemical and Biophysical Research Communications, Volume 466, Issue 2, 2015, Pages 232- 20. GUI, Dingkun, et al. Notoginsenoside R1 ameliorates podocyte adhesion under diabetic condition through α3β1 integrin upregulation in vitro and in vivo. Cellular Physiology and Biochemistry, 2014, 34.6: 1849-1862.https://doi.org/10.1159/000366384 21. Yongshen Ren, Jiao Ai, Xinqiao Liu, Shuai Liang, Yao Zheng, Xin Deng, Yan Li, Jing Wang, Xukun Deng, Lin-Lin Chen,Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational anal 22. Bian, Minjuan, et al. "Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration." Scientific reports 7.1 (2017): 1-15.https://doi.org/10.1038/s41598-017-06471-x 23. [IF=6.06] Yang Xiu et al."Simultaneous determination and difference evaluation of 14 ginsenosides in Panax ginseng roots cultivated in different areas and ages by high-performance liquid chromatography coupled with triple quadrupole mass spectrometer in the multipl 24. [IF=4.213] Qiangyuan Fan et al."Improved oral bioavailability of notoginsenoside R1 with sodium glycocholate-mediated liposomes: Preparation by supercritical fluid technology and evaluation in vitro and in vivo."Int J Pharmaceut. 2018 Dec;552:360 25. [IF=3.575] Ting Wang et al."Notoginsenoside R1 stimulates osteogenic function in primary osteoblasts via estrogen receptor signaling."Biochem Bioph Res Co. 2015 Oct;466:232 26. [IF=0] Dingkun Gui et al."Notoginsenoside R1 Ameliorates Podocyte Adhesion Under Diabetic Condition Through α3β1 Integrin Upregulation in Vitro and in Vivo."Cell Physiol Biochem. 2014;34(6):1849-1862 27. [IF=5.81] Xiaoyu Liu et al."Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway."Front Pharmacol. 2021; 12: 687394 28. [IF=5.34] Gui Zhou et al."Effects of Qing Chang Suppository Powder and its Ingredients on IL-17 Signal Pathway in HT-29 Cells and DSS-induced Mice."Phytomedicine. 2021 Jul;87:153573 29. [IF=4.759] Yi Zhang et al."Screening of inhibitors against histone demethylation jumonji domain-containing protein 3 by capillary electrophoresis."J Chromatogr A. 2020 Feb;1613:460625 30. [IF=4.36] Yongshen Ren et al."Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational analysis combined with UPLC-MS and molecular docking."J Ethnopharmacol. 2020 Oct;260:112955 31. [IF=4.162] Weixin Hou et al."The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats."Drug Des Dev Ther. 2021; 15: 3845–3862 32. [IF=4.142] Wang Chenxi et al."Rapid discovery of potential ADR compounds from injection of total saponins from Panax notoginseng using data-independent acquisition untargeted metabolomics."Analytical And Bioanalytical Chemistry. 2021 Oct 26 33. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206 34. [IF=3.932] Bo Cao et al."Protective effects of notoginsenoside R1 on acute lung injury in rats with sepsis."Ann Transl Med. 2021 Jun; 9(12): 996 35. [IF=3.882] Kunpeng Yin et al."Lanthanide Metal–Organic Framework-Based Fluorescent Sensor Arrays to Discriminate and Quantify Ingredients of Natural Medicine."Langmuir. 2021;37(17):5321–5328 36. [IF=3.69] Tianyuan Yu et al."Anti-inflammation effect of Qingchang suppository in ulcerative colitis through JAK2/STAT3 signaling pathway in vitro and in vivo."J Ethnopharmacol. 2021 Feb;266:113442 37. [IF=3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju 38. [IF=3.503] Jiajia Dong et al."Comparative pharmacokinetic analysis of raw and steamed Panax notoginseng roots in rats by UPLC-MS/MS for simultaneously quantifying seven saponins."Pharm Biol. 2021;59(1):653-661 39. [IF=3.205] Jie Tang et al."Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry."J Chromatogr B. 2021 Aug;1179:122827 40. [IF=3.199] Li Yuan et al."In Vitro Anti-hepatoma Activities of Notoginsenoside R1 Through Downregulation of Tumor Promoter miR-21."Digest Dis Sci. 2020 May;65(5):1364-1375 41. [IF=4.411] Xuanming Zhang et al.Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of Panax quinquefolius from Wendeng, China.Molecules. 2021 Jan;26(22):6829 42. [IF=1.978] Wang Rong-rong et al."Acute Developmental Toxicity of Panax notoginseng in Zebrafish Larvae."Chin J Integr Med. 2022 Jan;:1-8 43. [IF=3.373] Yu Yao et al."UPLC–MS/MS method for the determination of the herb composition of Tangshen formula and the in vivo pharmacokinetics of its metabolites in rat plasma."Phytochemical Analysis. 2021 Dec 14 44. [IF=5.811] He Zhang et al."Prevention Effect of Protopanaxadiol-Type Saponins Saponins and Protopanaxatriol-Type Saponins on Myelosuppression Mice Induced by Cyclophosphamide.."Frontiers in Pharmacology. 2022 Apr;13:845034-845034 |
三七皂甙 R1 - 简介
三七皂甙R1是从三七（学名：Panax notoginseng）的根茎中提取得到的一种药用成分。它是一种混合型皂甙，主要成分为三七皂苷R1，化学结构主要包括葡萄糖、鼠尾参甙G-R1、丹参甙R2、三七皂苷β-R1等。
三七皂甙R1具有多种药理活性，包括抗氧化、抗炎症、抗血小板凝集、保护心脑血管等作用。它可以促进血液循环，改善微循环，提高心肌供氧和心肌细胞代谢，从而起到调节血压、降低血脂和抗心血管疾病的作用。
在临床应用中，三七皂甙R1主要用于预防和治疗心脑血管疾病，如冠心病、心肌梗死、脑梗死等。另外，它还可以辅助治疗糖尿病和肿瘤等疾病。
三七皂甙R1的制法一般是通过水提、浓缩、结晶等工艺步骤从三七的根茎中提取得到。其中，主要提取三七皂苷R1这个成分。
从目前的研究来看，三七皂甙R1具有较好的安全性。其次，对于孕妇、哺乳期妇女和儿童等特殊人群应慎重使用。在使用过程中如出现过敏反应、消化道不适、头晕、头痛等不良反应，应及时停用并向医生咨询。
三七皂甙R1具有多种药理活性，包括抗氧化、抗炎症、抗血小板凝集、保护心脑血管等作用。它可以促进血液循环，改善微循环，提高心肌供氧和心肌细胞代谢，从而起到调节血压、降低血脂和抗心血管疾病的作用。
在临床应用中，三七皂甙R1主要用于预防和治疗心脑血管疾病，如冠心病、心肌梗死、脑梗死等。另外，它还可以辅助治疗糖尿病和肿瘤等疾病。
三七皂甙R1的制法一般是通过水提、浓缩、结晶等工艺步骤从三七的根茎中提取得到。其中，主要提取三七皂苷R1这个成分。
从目前的研究来看，三七皂甙R1具有较好的安全性。其次，对于孕妇、哺乳期妇女和儿童等特殊人群应慎重使用。在使用过程中如出现过敏反应、消化道不适、头晕、头痛等不良反应，应及时停用并向医生咨询。
最后更新：2024-04-09 21:00:56
供应商列表
提供多种规格现货供应
产品名: 三七皂苷R1(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IN02401
产地: 北京
包装: 1ml/瓶
规格: IN02401-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
提供多种规格现货供应
产品名: 三七皂苷R1(10mM in DMSO,无菌) 去供应商网站查看 询盘CAS: IN02401
产地: 北京
包装: 1ml/瓶
规格: IN02401-1ml
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 17801761073(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 17801761073
产品描述: 索莱宝直销,欢迎来询
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！